Article
P2RX7: expression responds to sleep deprivation and associates with rapid cycling in bipolar disorder type 1.
PloS one - 1 Jan 2012
Backlund Lena, Lavebratt Catharina, Frisén Louise, Nikamo Pernilla, Hukic Sudic Dzana, Träskman-Bendz Lil, Landén Mikael, Edman Gunnar, Vawter Marquis P, Ösby Urban, Schalling Martin
Abstract excerpt
CONTEXT: Rapid cycling is a severe form of bipolar disorder with an increased rate of episodes that is particularly treatment-responsive to chronotherapy and stable sleep-wake cycles. We hypothesized that the P2RX7 gene would be affected by sleep deprivation and be implicated in rapid cycling. OBJECTIVES: To assess whether P2RX7 expression is affected by total sleep deprivation and if variation in P2RX7 is...
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