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Article

P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2009

Green Elaine K, Grozeva Detelina, Raybould Rachel, Elvidge Gareth, Macgregor Stuart, Craig Ian, Farmer Anne, McGuffin Peter, Forty Liz, Jones Lisa, Jones Ian, O'Donovan Mick C, Owen Mike J, Kirov George, Craddock Nick

Abstract excerpt

The chromosomal region 12q24 has been previously implicated by linkage studies of both bipolar disorder and unipolar mood disorder and we have reported two pedigrees segregating both bipolar disorder and Darier's disease that show linkage across this region. The gene P2RX7 is located in this chromosomal region and has been recently reported as a susceptibility gene for bipolar disorder and unipolar depression....

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Identifiers

PMID: 19160446
DOI: 10.1002/ajmg.b.30931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?PMID 19160446Read ↗

Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders.Semantic proximity Read ↗

Variation in P2RX7 candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples.Semantic proximity Read ↗

Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder.Semantic proximity Read ↗

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.Semantic proximity Read ↗

Phenome-wide association study of P2RX7 identifies schizophrenia and mood disorders as primary associated phenotypes.Semantic proximity Read ↗

The P2RX7 polymorphism rs2230912 is associated with depression: A meta-analysis.Semantic proximity Read ↗

P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts.Semantic proximity Read ↗

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Genetic linkage mapping for a susceptibility locus to bipolar illness: chromosomes 2, 3, 4, 7, 9, 10p, 11p, 22, and Xpter.Semantic proximity Read ↗

Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approach.Semantic proximity Read ↗

Variation in the purinergic P2RX(7) receptor gene and schizophrenia.Semantic proximity Read ↗

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