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Article

Phenome-wide association study of P2RX7 identifies schizophrenia and mood disorders as primary associated phenotypes.

Journal of affective disorders - 1 Jun 2026

Zhu Ling, Mao Qiao, Luo Zhixiong, Chen Bin, Zhang Yong, Lu Xiaowei, Liu Ping, Ji Jiawu, Wang Xiaoping, Wang Kesheng, Pan Xinghua, Cao Yuping, Liu Na, Zheng Jianming, Wang Fan, Yang Kebing, Yang Fude, Yu Zongyang, Hu Jia, Luo Jennifer, Zuo Lingjun, Wang Zhiren, Luo Xingguang, Guo Xiaoyun

Abstract excerpt

OBJECTIVES: P2RX7 has been implicated in bipolar disorder, major depressive disorder, schizophrenia, anxiety disorders, Alzheimer's disease, and Parkinson's disease. However, the specificity and comparability of these associations remain unclear. This study aimed to systematically evaluate multiple neuropsychiatric disorders to identify those most robustly associated with P2RX7. METHODS: We analyzed 1861 imputed...

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Source

Identifiers

PMID: 41672153
DOI: 10.1016/j.jad.2026.121327

Genes

P2RX7
TH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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