Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of a lung cancer risk haplotype in the IL1B gene regulatory region.

Journal of human genetics - 26 Nov 2012

Landvik Nina E, Hart Kent, Haugen Aage, Zienolddiny Shanbeh

Abstract excerpt

Interleukin-1β (IL-1β), encoded by the IL1B gene, is a cytokine important in regulation of the inflammatory response. Elevated levels of IL1B expression have been associated with risk of gastric and lung cancer. We previously reported that a certain haplotype containing four single-nucleotide polymorphisms (SNPs) (-3893G, -1464G, -511C and -31T; GGCT) in the IL1B gene regulatory region was associated with lung...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cloning, Molecular
Share to Gene Expression Regulation
Share to Interleukin-1beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Regulatory Sequences, Nucleic Acid

Share to Transcription Factors

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 22951596
DOI: 10.1038/jhg.2012.106

Genes

GGCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of a lung cancer risk haplotype in the IL1B gene regulatory region.PMID 22951596Read ↗

A specific interleukin-1B haplotype correlates with high levels of IL1B mRNA in the lung and increased risk of non-small cell lung cancer.Semantic proximity Read ↗

Current evidences on IL1B polymorphisms and lung cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

Polymorphisms of the interleukin-1 beta gene are associated with increased risk of non-small cell lung cancer.Semantic proximity Read ↗

Molecular characterization of a cancer-related single nucleotide polymorphism in the pro-inflammatory interleukin-1B gene.Semantic proximity Read ↗

Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk.Semantic proximity Read ↗

Interleukin 1 beta (IL1B) promoter polymorphism and cancer risk: evidence from 47 published studies.Semantic proximity Read ↗

Systematic evaluation of genetic variants in the inflammation pathway and risk of lung cancer.Semantic proximity Read ↗

Functional variants in the promoter of interleukin-1beta are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population.Semantic proximity Read ↗

A two-SNP IL-6 promoter haplotype is associated with increased lung cancer risk.Semantic proximity Read ↗

Common variants of pro-inflammatory gene IL1B and interactions with PPP1R13L and POLR1G in relation to lung cancer among Northeast Chinese.Semantic proximity Read ↗

IL1B gene polymorphisms, age and the risk of non-small cell lung cancer in a Chinese population.Semantic proximity Read ↗

Allele-specific induction of IL1B -31T/C promoter polymorphism by lung carcinogens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.