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A specific interleukin-1B haplotype correlates with high levels of IL1B mRNA in the lung and increased risk of non-small cell lung cancer.

Carcinogenesis - 1 Jul 2009

Landvik Nina E, Hart Kent, Skaug Vidar, Stangeland Lodve B, Haugen Aage, Zienolddiny Shanbeh

Abstract excerpt

Epidemiological evidence suggests a relationship between chronic inflammation and lung cancer. Inflammation in the lung may be modulated by host genetic factors such as polymorphisms in inflammatory genes. Identification of polymorphisms in inflammatory genes may help understanding interindividual differences in susceptibility to lung cancer. We have investigated single-nucleotide polymorphisms (SNPs) and their...

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PMID: 19461122
DOI: 10.1093/carcin/bgp122

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