Article
Interleukin 1 beta (IL1B) promoter polymorphism and cancer risk: evidence from 47 published studies.
Mutagenesis - 1 Sept 2011
He Bangshun, Zhang Ying, Pan Yuqin, Xu Yeqiong, Gu Ling, Chen Liping, Wang Shukui
Abstract excerpt
Interleukin 1β (IL-1B) is a pro-inflammatory cytokine against infection, playing an important role in the pathogenesis of cancers. The -31T/C polymorphism of the interleukin 1β gene (IL1B) has been implicated in cancer risk through its influence on the IL1B transcription. However, results from studies are conflicting. To clarify the association, a meta-analysis was performed for 11 125 cases and 14 415 controls...
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