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Article

A two-SNP IL-6 promoter haplotype is associated with increased lung cancer risk.

Journal of cancer research and clinical oncology - 1 Feb 2013

Chen Jun, Liu Reng-Yun, Yang Lixin, Zhao Jun, Zhao Xueying, Lu Daru, Yi Nengjun, Han Baohui, Chen Xiao-Feng, Zhang Kui, He Jun, Lei Zhe, Zhou Yifeng, Pasche Boris, Li Xiangdong, Zhang Hong-Tao

Abstract excerpt

BACKGROUND: Aberrant expression of interleukin-6 (IL-6) may play an important role in lung carcinogenesis. Whether IL-6 promoter haplotypes are associated with lung cancer risk and their functions have not yet been studied. We tested the hypothesis that single-nucleotide polymorphism (SNP) and/or haplotypes of IL-6 promoter are associated with risk of lung cancer. METHODS: Two functional IL-6 promoter SNPs...

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Identifiers

PMID: 23052692
DOI: 10.1007/s00432-012-1314-z
PMCID: PMC4535449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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