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Article

Inward rectification by polyamines in mouse Kir2.1 channels: synergy between blocking components.

The Journal of physiology - 1 Jul 2003

Xie Lai-Hua, John Scott A, Weiss James N

Abstract excerpt

We recently characterized two distinct mechanisms by which the polyamine spermine blocks Kir2.1 channels: (1) by reduction of negative surface charges in the cytoplasmic pore, thereby reducing single-channel conductance, and (2) by direct open channel transmembrane pore block. The extent to which the surface charge reduction component is mediated by passive surface charge screening versus binding of polyamines to...

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Identifiers

PMID: 12740427
DOI: 10.1113/jphysiol.2003.043117
PMCID: PMC2343018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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