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Article

Inward rectification in KATP channels: a pH switch in the pore.

The EMBO journal - 15 Feb 1999

Baukrowitz T, Tucker S J, Schulte U, Benndorf K, Ruppersberg J P, Fakler B

Abstract excerpt

Inward-rectifier potassium channels (Kir channels) stabilize the resting membrane potential and set a threshold for excitation in many types of cell. This function arises from voltage-dependent rectification of these channels due to blockage by intracellular polyamines. In all Kir channels studied to date, the voltage-dependence of rectification is either strong or weak. Here we show that in cardiac as well as in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10022827
DOI: 10.1093/emboj/18.4.847
PMCID: PMC1171177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Inward rectification in KATP channels: a pH switch in the pore.PMID 10022827Read ↗

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Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH.Semantic proximity Read ↗

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