Article
Aldosterone deficiency adversely affects pregnancy outcome in mice.
Pflugers Archiv : European journal of physiology - 1 Oct 2012
Todkar Abhijeet, Di Chiara Marianna, Loffing-Cueni Dominique, Bettoni Carla, Mohaupt Markus, Loffing Johannes, Wagner Carsten A
Abstract excerpt
Circulating aldosterone levels are increased in human pregnancy. Inadequately low aldosterone levels as present in preeclampsia, a life-threatening disease for both mother and child, are discussed to be involved in its pathogenesis or severity. Moreover, inactivating polymorphisms in the aldosterone synthase gene have been detected in preeclamptic women. Here, we used aldosterone synthase-deficient (AS(-/-)) mice...
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