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Article

The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jul 2015

Gillis Ellen E, Williams Jan M, Garrett Michael R, Mooney Jennifer N, Sasser Jennifer M

Abstract excerpt

The mechanisms of the pathogenesis of preeclampsia, a leading cause of maternal morbidity and death worldwide, are poorly understood in part due to a lack of spontaneous animal models of the disease. We hypothesized that the Dahl salt-sensitive (S) rat, a genetic model of hypertension and kidney disease, is a spontaneous model of superimposed preeclampsia. The Dahl S was compared with the Sprague-Dawley (SD) rat,...

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Identifiers

PMID: 25904684
DOI: 10.1152/ajpregu.00377.2014
PMCID: PMC4491533

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