Article
High aldosterone-to-renin variants of CYP11B2 and pregnancy outcome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jun 2009
Escher Geneviève, Cristiano Martino, Causevic Maja, Baumann Marc, Frey Felix J, Surbek Daniel, Mohaupt Markus G
Abstract excerpt
BACKGROUND: Increased aldosterone concentrations and volume expansion of normal pregnancies are hallmarks of normal pregnancies and blunted in pre-eclampsia. Accordingly, we hypothesized an active mineralocorticoid system to protect from pre-eclampsia. METHODS: In pregnant women (normotensive n = 44; pre-eclamptic n = 48), blood pressure, urinary tetrahydro-aldosterone excretion and activating polymorphisms (SF-1...
Topics
- Adult
- Aldosterone
- Base Sequence
- Blood Pressure
- Case-Control Studies
- Cytochrome P-450 CYP11B2
- DNA Primers
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Haplotypes
- Humans