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Article

Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism.

Journal of the American Heart Association - 22 Feb 2013

McGraw Adam P, Bagley Jessamyn, Chen Wei-Sheng, Galayda Carol, Nickerson Heather, Armani Andrea, Caprio Massimiliano, Carmeliet Peter, Jaffe Iris Z

Abstract excerpt

BACKGROUND: Aldosterone levels correlate with the incidence of myocardial infarction and mortality in cardiovascular patients. Aldosterone promotes atherosclerosis in animal models, but the mechanisms are poorly understood. METHODS AND RESULTS: Aldosterone was infused to achieve pathologically relevant levels that did not increase blood pressure in the atherosclerosis-prone apolipoprotein E-knockout mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23525413
DOI: 10.1161/JAHA.112.000018
PMCID: PMC3603255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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