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Article

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice.

The Journal of clinical investigation - 1 Oct 2006

Li Manyu, Yee Della, Magnuson Terry R, Smithies Oliver, Caron Kathleen M

Abstract excerpt

Adrenomedullin (AM) is a multifunctional peptide vasodilator that is essential for life. Plasma AM expression dramatically increases during pregnancy, and alterations in its levels are associated with complications of pregnancy including fetal growth restriction (FGR) and preeclampsia. Using AM+/- female mice with genetically reduced AM expression, we demonstrate that fetal growth and placental development are...

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Identifiers

PMID: 16981008
DOI: 10.1172/JCI28462
PMCID: PMC1564429

Genes

FGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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