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Article

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for <i>In Vitro</i> Investigation

31 Aug 2012

Abstract excerpt

RATIONALE: Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity and function, and its regulation of cell phenotype is a major aspect of cell biology. However, standard in vitro culture approaches are of unclear physiologic relevance because they do not mimic the compositional, architectural, or distensible nature of a living organ. In the lung, fibroblasts exist in ECM-rich...

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PMID: 22936357
DOI: 10.1164/rccm.201204-0754oc

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