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Article

Absence of O antigen suppresses Shigella flexneri IcsA autochaperone region mutations.

Microbiology (Reading, England) - 1 Nov 2012

Teh Min Yan, Tran Elizabeth Ngoc Hoa, Morona Renato

Abstract excerpt

The Shigella flexneri IcsA (VirG) protein is a polarly distributed autotransporter protein. IcsA functions as a virulence factor by interacting with the host actin regulatory protein N-WASP, which in turn activates the Arp2/3 complex, initiating actin polymerization. Formation of F-actin comet tails allows bacterial cell-to-cell spreading. Although various accessory proteins such as periplasmic chaperones and the...

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Identifiers

PMID: 22936034
DOI: 10.1099/mic.0.062471-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Absence of O antigen suppresses Shigella flexneri IcsA autochaperone region mutations.PMID 22936034Read ↗

Identification of Shigella flexneri IcsA residues affecting interaction with N-WASP, and evidence for IcsA-IcsA co-operative interaction.Semantic proximity Read ↗

Multicopy icsA is able to suppress the virulence defect caused by the wzz(SF) mutation in Shigella flexneri.Semantic proximity Read ↗

The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function.Semantic proximity Read ↗

MxiC is secreted by and controls the substrate specificity of the <i>Shigella flexneri</i> type III secretion apparatusSemantic proximity Read ↗

Contribution of the periplasmic chaperone Skp to efficient presentation of the autotransporter IcsA on the surface of Shigella flexneri.Semantic proximity Read ↗

The inverse autotransporter intimin exports its passenger domain via a hairpin intermediate.Semantic proximity Read ↗

A system for identifying post-invasion functions of invasion genes: requirements for the Mxi-Spa type III secretion pathway of Shigella flexneri in intercellular dissemination.Semantic proximity Read ↗

Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures.Semantic proximity Read ↗

IcsA surface presentation in Shigella flexneri requires the periplasmic chaperones DegP, Skp, and SurA.Semantic proximity Read ↗

A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri.Semantic proximity Read ↗

Shigella flexneri cell-to-cell spread, and growth and inflammation in mice, is limited by the outer membrane protease IcsP.Semantic proximity Read ↗

Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility.Semantic proximity Read ↗

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