Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gfi1 integrates progenitor versus granulocytic transcriptional programming.

Blood - 28 May 2009

Horman Shane R, Velu Chinavenmeni S, Chaubey Aditya, Bourdeau Tristan, Zhu Jinfang, Paul William E, Gebelein Brian, Grimes H Leighton

Abstract excerpt

In patients with severe congenital neutropenia (SCN) and mice with growth factor independent-1 (Gfi1) loss of function, arrested myeloid progenitors accumulate, whereas terminal granulopoiesis is blocked. One might assume that Gfi-null progenitors accumulate because they lack the ability to differentiate. Instead, our data indicate that Gfi1 loss of function deregulates 2 separable transcriptional programs, one...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Granulocytes

Share to Homeodomain Proteins

Share to Leukemia

Share to Myeloid Ecotropic Viral Integration Site 1 Protein

Share to Neoplasm Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19346496
DOI: 10.1182/blood-2008-09-179747
PMCID: PMC2689047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gfi1 integrates progenitor versus granulocytic transcriptional programming.PMID 19346496Read ↗

Mouse models of neutropenia reveal progenitor-stage-specific defects.Semantic proximity Read ↗

Gfi1–cells and circuits: unraveling transcriptional networks of development and diseaseSemantic proximity Read ↗

Gfi-1 Oncoproteins in HematopoiesisSemantic proximity Read ↗

Gfi1 regulates miR-21 and miR-196b to control myelopoiesisSemantic proximity Read ↗

Growth factor independent-1 Maintains Notch1-Dependent Transcriptional Programming of Lymphoid PrecursorsSemantic proximity Read ↗

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.Semantic proximity Read ↗

Transcription Factor GFI1B in Health and DiseaseSemantic proximity Read ↗

Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation.Semantic proximity Read ↗

The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.Semantic proximity Read ↗

Dose-dependent role of Gfi1 in murine hematopoietic stem cell self-renewal and differentiationSemantic proximity Read ↗

Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells.Semantic proximity Read ↗

Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.