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Article

A subset of papillary thyroid carcinomas contain KRAS mutant subpopulations at levels above normal thyroid.

Molecular carcinogenesis - 1 Feb 2014

Myers Meagan B, McKim Karen L, Parsons Barbara L

Abstract excerpt

The molecular pathogenesis of papillary thyroid carcinoma (PTC) is largely attributed to chromosomal rearrangements and point mutations in genes within the MAPK pathway (i.e., BRAF and RAS). Despite KRAS being the 6th most frequently mutated gene for all cancers, the reported frequency in thyroid cancer is only 2%. This may be due, in part, to the use of insensitive mutation detection methods such as DNA...

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Source

Identifiers

PMID: 22930660
DOI: 10.1002/mc.21953

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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