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Article

Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.

Cancer research - 1 Jun 2009

Ricarte-Filho Julio C, Ryder Mabel, Chitale Dhananjay A, Rivera Michael, Heguy Adriana, Ladanyi Marc, Janakiraman Manickam, Solit David, Knauf Jeffrey A, Tuttle R Michael, Ghossein Ronald A, Fagin James A

Abstract excerpt

Patients with poorly differentiated thyroid cancers (PDTC), anaplastic thyroid cancers (ATC), and radioactive iodine-refractory (RAIR) differentiated thyroid cancers have a high mortality, particularly if positive on [(18)F]fluorodeoxyglucose (FDG)-positron emission tomography (PET). To obtain co...

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Share to Carcinoma, Papillary, Follicular
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Iodine Radioisotopes

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Source

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Identifiers

PMID: 19487299
DOI: 10.1158/0008-5472.CAN-09-0727
PMCID: PMC2690720

Genes

BRAF
AKT1
HRAS
KRAS
NRAS
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19487299-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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