Article
The associations between RAS mutations and clinical characteristics in follicular thyroid tumors: new insights from a single center and a large patient cohort.
Thyroid : official journal of the American Thyroid Association - 1 Jul 2012
Fukahori Michiko, Yoshida Akira, Hayashi Hiroyuki, Yoshihara Mitsuyo, Matsukuma Shoichi, Sakuma Yuji, Koizume Shiro, Okamoto Naoyuki, Kondo Tetsuo, Masuda Munetake, Miyagi Yohei
Abstract excerpt
BACKGROUND: Many studies on thyroid follicular tumors have reported the presence of somatic mutations to three forms of RAS: HRAS, KRAS, and NRAS. However, the frequency and clinical significance of these RAS mutations remain unclear, in large part due to the different methodologies being used for mutation analysis and the limited number of cases featured in studies. To clarify the significance of RAS mutations,...
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