Variation in the Evolution and Sequences of Proglucagon and the Receptors for Proglucagon-Derived Peptides in Mammals.

doi:10.3389/fendo.2021.700066

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Variation in the Evolution and Sequences of Proglucagon and the Receptors for Proglucagon-Derived Peptides in Mammals.

Frontiers in endocrinology - 1 Jan 2021

Irwin David M

Abstract excerpt

The mammalian proglucagon gene (Gcg) encodes three glucagon like sequences, glucagon, glucagon-like peptide-1 (GLP-1), and glucagon-like peptide-2 that are of similar length and share sequence similarity, with these hormones having cell surface receptors, glucagon receptor (Gcgr), GLP-1 receptor (Glp1r), and GLP-2 receptor (Glp2r), respectively. Gcgr, Glp1r, and Glp2r are all class B1 G protein-coupled receptors...

Topics

Amino Acid Sequence
Animals
Evolution, Molecular
Genetic Variation
Genome
Glucagon
Glucagon-Like Peptide 1
Glucagon-Like Peptide 2
Glucagon-Like Peptide-1 Receptor
Glucagon-Like Peptide-2 Receptor
Mammals
Phylogeny
Proglucagon
Receptors, Glucagon

Source

Open in PubMed Open full text

Identifiers

PMID: 34322093
DOI: 10.3389/fendo.2021.700066
PMCID: PMC8312260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics