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Article

PAC1 null females display decreased fertility.

Annals of the New York Academy of Sciences - 1 Jan 2000

Jamen F, Rodriguez-Henche N, Pralong F, Jegou B, Gaillard R, Bockaert J, Brabet P

Abstract excerpt

We report here that PAC1 KO females display decreased fertility, whereas male fertility was normal. ICC on pituitary section showed that FSH, LH, and prolactin synthesis were not affected in KO mice. Moreover, the pituitary-gonadal axis responded properly to an acute fasting test in KO mice. Hence, the phenotype of PAC1 null mice provides clear evidence for the role of PAC1 receptor in reproduction process.

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Source

Identifiers

PMID: 11193864
DOI: 10.1111/j.1749-6632.2000.tb07004.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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