Transplantable glucagonomas derived from pluripotent rat islet tumor tissue cause severe anorexia and adipsia.

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Article

Transplantable glucagonomas derived from pluripotent rat islet tumor tissue cause severe anorexia and adipsia.

Scandinavian journal of clinical and laboratory investigation. Supplementum - 1 Jan 1995

Madsen O D, Karlsen C, Blume N, Jensen H I, Larsson L I, Holst J J

Abstract excerpt

From pluripotent pancreatic rat islet tumor tissue we have previously reported the isolation of stable transplantable glucagonoma tumor phenotypes in rats characterized by acute onset of anorexia. We now report that these tumors also cause severe adipsia. Food and water intake is reduced by more than 95% and is immediately cured upon tumor removal. Four anorectic tumor lines were all characterized as glucagonomas...

Topics

Animals
Anorexia
Body Weight
Drinking
Eating
Glucagon
Glucagonoma
Islets of Langerhans
Mice
Mice, Inbred C57BL
Mice, Obese

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Transplantation

Pancreatic Neoplasms

Peptide Fragments

Phenotype

Proglucagon

Protein Precursors

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 7652479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7652479-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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