Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy.

Endocrinology - 1 Apr 2009

Huang Carol, Snider Frances, Cross James C

Abstract excerpt

Increased islet mass is an adaptive mechanism that occurs to combat insulin resistance during pregnancy. Prolactin (PRL) can enhance beta-cell proliferation and insulin secretion in vitro, yet whether it is PRL or other pregnancy-related factors that mediate these adaptive changes during pregnancy is unknown. The objective of this study was to determine whether prolactin receptor (Prlr) is required for normal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glucose
Share to Glucose Intolerance
Share to Glucose Tolerance Test

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homeostasis

Share to Insulin-Secreting Cells

Share to Islets of Langerhans

Share to Mice, Mutant Strains

Share to Receptors, Prolactin

Source

Identifiers

PMID: 19036882
DOI: 10.1210/en.2008-1003

Genes

PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy.PMID 19036882Read ↗

Beta-cell adaptation to metabolic stresses requires prolactin receptor signalingSemantic proximity Read ↗

Pregnancy Hyperglycemia in Prolactin Receptor Mutant, but Not Prolactin Mutant, Mice and Feeding-Responsive Regulation of Placental Lactogen Genes Implies Placental Control of Maternal Glucose Homeostasis.Semantic proximity Read ↗

Prolactin receptors are critical to the adaptation of islets to pregnancy.Semantic proximity Read ↗

Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring.Semantic proximity Read ↗

A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomicsSemantic proximity Read ↗

β‐Cell adaptation in pregnancySemantic proximity Read ↗

Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.Semantic proximity Read ↗

Prolactin: A Hormone at the Crossroads of NeuroimmunoendocrinologySemantic proximity Read ↗

A prolactin family paralog regulates reproductive adaptations to a physiological stressor.Semantic proximity Read ↗

Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2.Semantic proximity Read ↗

Prolactin-stimulated survivin induction is required for beta cell mass expansion during pregnancy in mice.Semantic proximity Read ↗

Prolactin Receptors and Placental Lactogen Drive Male Mouse Pancreatic Islets to Pregnancy-Related mRNA ChangesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.