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Article

Restoration of topoisomerase 2 function by complementation of defective monomers in Drosophila.

Genetics - 1 Nov 2012

Hohl Amber M, Thompson Morgan, Soshnev Alexey A, Wu Jianhong, Morris James, Hsieh Tao-Shih, Wu C-Ting, Geyer Pamela K

Abstract excerpt

Type II topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chromosome segregation. These proteins alter DNA topology by generating transient enzyme-linked double-strand breaks for passage of one DNA strand through another. The central role of type II topoisomerases in DNA metabolism has made these enzymes targets for anticancer drugs. Here, we describe a...

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Identifiers

PMID: 22923380
DOI: 10.1534/genetics.112.144006
PMCID: PMC3522162

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