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Identification of Suppressors of top-2 Embryonic Lethality in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 9 Apr 2020

Bhandari Nirajan, Rourke Christine, Wilmoth Thomas, Bheemreddy Alekya, Schulman David, Collins Dina, Smith Harold E, Golden Andy, Jaramillo-Lambert Aimee

Abstract excerpt

Topoisomerase II is an enzyme with important roles in chromosome biology. This enzyme relieves supercoiling and DNA and RNA entanglements generated during mitosis. Recent studies have demonstrated that Topoisomerase II is also involved in the segregation of homologous chromosomes during the first meiotic division. However, the function and regulation of Topoisomerase II in meiosis has not been fully elucidated....

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Alleles
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Meiosis
Mitosis

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PMID: 32086248
DOI: 10.1534/g3.119.400927
PMCID: PMC7144083

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