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The analysis of mutant alleles of different strength reveals multiple functions of topoisomerase 2 in regulation of Drosophila chromosome structure.

PLoS genetics - 1 Oct 2014

Mengoli Valentina, Bucciarelli Elisabetta, Lattao Ramona, Piergentili Roberto, Gatti Maurizio, Bonaccorsi Silvia

Abstract excerpt

Topoisomerase II is a major component of mitotic chromosomes but its role in the assembly and structural maintenance of chromosomes is rather controversial, as different chromosomal phenotypes have been observed in various organisms and in different studies on the same organism. In contrast to vertebrates that harbor two partially redundant Topo II isoforms, Drosophila and yeasts have a single Topo II enzyme. In...

Topics

Alleles
Animals
Chromatin
Chromosome Structures
DNA Topoisomerases, Type II
Drosophila melanogaster
Gene Expression Regulation
Heterochromatin
Male
Mitosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Spermatocytes

X Chromosome

Y Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 25340516
DOI: 10.1371/journal.pgen.1004739
PMCID: PMC4207652

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