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Article

Mutations in tyrosyl-DNA phosphodiesterase 2 suppress top-2 induced chromosome segregation defects during Caenorhabditis elegans spermatogenesis.

The Journal of biological chemistry - 1 Jul 2024

Kwah Ji Kent, Bhandari Nirajan, Rourke Christine, Gassaway Gabriella, Jaramillo-Lambert Aimee

Abstract excerpt

Meiosis reduces ploidy through two rounds of chromosome segregation preceded by one round of DNA replication. In meiosis I, homologous chromosomes segregate, while in meiosis II, sister chromatids separate from each other. Topoisomerase II (Topo II) is a conserved enzyme that alters DNA structure by introducing transient double-strand breaks. During mitosis, Topo II relieves topological stress associated with...

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Identifiers

PMID: 38844130
DOI: 10.1016/j.jbc.2024.107446
PMCID: PMC11261448

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