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Article

An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle.

Free radical biology & medicine - 1 Jan 2017

Niemann Jan, Johne Cindy, Schröder Susanne, Koch Franziska, Ibrahim Saleh M, Schultz Julia, Tiedge Markus, Baltrusch Simone

Abstract excerpt

Mitochondrial dysfunction affects liver metabolism, but it remains unclear whether this interferes with normal liver aging. We investigated several mitochondrial pathways in hepatocytes and liver tissue from a conplastic mouse strain compared with the control C57BL/6NTac strain over 18 months of life. The C57BL/6NTac-mtNODLtJ mice differed from C57BL/6NTac mice by a point mutation in mitochondrial-encoded subunit...

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Identifiers

PMID: 27890640
DOI: 10.1016/j.freeradbiomed.2016.11.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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