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Article

Mutated ATP synthase induces oxidative stress and impaired insulin secretion in beta-cells of female BHE/cdb rats.

Diabetes/metabolism research and reviews - 1 Jan 2000

Saleh Monique C, Fatehi-Hassanabad Zahra, Wang Rennian, Nino-Fong Rodolpho, Wadowska Dorota W, Wright Glenda M, Harper Mary-Ellen, Chan Catherine B

Abstract excerpt

BACKGROUND: Adenosine triphosphate (ATP) is a critical determinant of beta-cell insulin secretion in response to glucose. BHE/cdb rats have a mutation in ATP synthase that limits ATP production, yet develop mild diabetes only with ageing. We investigated the cellular basis for reduced insulin sec...

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PMID: 18273840
DOI: 10.1002/dmrr.819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18273840-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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