Article
The mtDNA nt7778 G/T polymorphism augments formation of lymphocytic foci but does not aggravate cerulein-induced acute pancreatitis in mice.
PloS one - 1 Jan 2014
Müller Sarah, Krüger Burkhard, Lange Falko, Bock Cristin N, Nizze Horst, Glass Änne, Ibrahim Saleh M, Jaster Robert
Abstract excerpt
A polymorphism in the ATP synthase 8 (ATP8) gene of the murine mitochondrial genome, G-to-T transversion at position 7778, has been suggested to increase susceptibility to multiple autoimmune diseases, including autoimmune pancreatitis (AIP). The polymorphism also induces mitochondrial reactive oxygen species generation, secretory dysfunction and β-cell mass adaptation. Here, we have used two conplastic mouse...
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