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Article

Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.

PLoS genetics - 1 Jan 2012

Inouye Michael, Ripatti Samuli, Kettunen Johannes, Lyytikäinen Leo-Pekka, Oksala Niku, Laurila Pirkka-Pekka, Kangas Antti J, Soininen Pasi, Savolainen Markku J, Viikari Jorma, Kähönen Mika, Perola Markus, Salomaa Veikko, Raitakari Olli, Lehtimäki Terho, Taskinen Marja-Riitta, Järvelin Marjo-Riitta, Ala-Korpela Mika, Palotie Aarno, de Bakker Paul I W

Abstract excerpt

Association testing of multiple correlated phenotypes offers better power than univariate analysis of single traits. We analyzed 6,600 individuals from two population-based cohorts with both genome-wide SNP data and serum metabolomic profiles. From the observed correlation structure of 130 metabolites measured by nuclear magnetic resonance, we identified 11 metabolic networks and performed a multivariate...

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Identifiers

PMID: 22916037
DOI: 10.1371/journal.pgen.1002907
PMCID: PMC3420921

Genes

AQP9
SERPINA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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