The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.

doi:10.1016/0092-8674(95)90205-8

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Article

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.

Cell - 15 Dec 1995

Sundaram M, Han M

Abstract excerpt

Vulval induction in C. elegans is controlled by a highly conserved signaling pathway similar to the RTK-Ras-MAPK cascade in mammals. By screening for suppressors of the Multivulva phenotype caused by an activated let-60 ras allele, we isolated mutations in a gene, ksr-1, that acts as a positive m...

Topics

Amino Acid Sequence
Animals
Base Sequence
Caenorhabditis elegans
Chromosome Mapping
Cloning, Molecular
Embryonic Induction
Epistasis, Genetic
Female
Gene Dosage
Genes, Helminth
Genes, Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Protein Serine-Threonine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-raf

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 8521513
DOI: 10.1016/0092-8674(95)90205-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8521513-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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