Article
C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites.
Development (Cambridge, England) - 1 Feb 2004
Kao Gautam, Tuck Simon, Baillie David, Sundaram Meera V
Abstract excerpt
Protein phosphatase 2A (PP2A) can both positively and negatively influence the Ras/Raf/MEK/ERK signaling pathway, but its relevant substrates are largely unknown. In C. elegans, the PR55/B regulatory subunit of PP2A, which is encoded by sur-6, positively regulates Ras-mediated vulval induction and acts at a step between Ras and Raf. We show that the catalytic subunit (C) of PP2A, which is encoded by let-92, also...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.