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Article

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.

Genes & development - 1 Jan 1994

Lackner M R, Kornfeld K, Miller L M, Horvitz H R, Kim S K

Abstract excerpt

During development of the Caenorhabditis elegans hermaphrodite, the gonadal anchor cell induces nearby Pn.p cells to adopt vulval fates. The response to this signal is mediated by a receptor tyrosine kinase signal transduction pathway that has been remarkably well conserved during metazoan evolution. Because mitogen-activated protein (MAP) kinases are activated by receptor tyrosine kinase pathways in vertebrate...

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Identifiers

PMID: 8299936
DOI: 10.1101/gad.8.2.160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.PMID 8299936Read ↗

Genetic analysis of the Caenorhabditis elegans MAP kinase gene mpk-1.Semantic proximity Read ↗

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.Semantic proximity Read ↗

Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase.Semantic proximity Read ↗

lin-25, a gene required for vulval induction in Caenorhabditis elegans.Semantic proximity Read ↗

lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans.Semantic proximity Read ↗

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.Semantic proximity Read ↗

Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans.Semantic proximity Read ↗

C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation.Semantic proximity Read ↗

Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans.Semantic proximity Read ↗

Drosophila MAP kinase kinase suppresses the vulvaless phenotype of lin-3, let-23 and lin-45 mutations in Caenorhabditis elegans.Semantic proximity Read ↗

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.Semantic proximity Read ↗

MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction.Semantic proximity Read ↗

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