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Article

Passenger mutations as a marker of clonal cell lineages in emerging neoplasia.

Seminars in cancer biology - 1 Oct 2010

Salk Jesse J, Horwitz Marshall S

Abstract excerpt

Cancer arises as the result of a natural selection process among cells of the body, favoring lineages bearing somatic mutations that bestow them with a proliferative advantage. Of the thousands of mutations within a tumor, only a small fraction functionally drive its growth; the vast majority are mere passengers of minimal biological consequence. Yet the presence of any mutation, independent of its role in...

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Source

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Identifiers

PMID: 20951806
DOI: 10.1016/j.semcancer.2010.10.008
PMCID: PMC2993762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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