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Article

The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts.

Autophagy - 1 Oct 2012

Bravo-San Pedro José M, Gómez-Sánchez Rubén, Niso-Santano Mireia, Pizarro-Estrella Elisa, Aiastui-Pujana Ana, Gorostidi Ana, Climent Vicente, López de Maturana Rakel, Sanchez-Pernaute Rosario, López de Munain Adolfo, Fuentes José M, González-Polo Rosa A

Abstract excerpt

The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-ri...

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Source

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Identifiers

PMID: 22914360
DOI: 10.4161/auto.21270
PMCID: PMC3463455

Genes

MAPK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22914360-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts.PMID 22914360Read ↗

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