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G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.

Toxicology - 3 Oct 2014

Yakhine-Diop Sokhna M S, Bravo-San Pedro José M, Gómez-Sánchez Rubén, Pizarro-Estrella Elisa, Rodríguez-Arribas Mario, Climent Vicente, Aiastui Ana, López de Munain Adolfo, Fuentes José M, González-Polo Rosa A

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder of unknown etiology. It is considered as a multifactorial disease dependent on environmental and genetic factors. Deregulation in cell degradation has been related with a significant increase in cell damage, becoming a target for studies on the PD etiology. In the present study, we have characterized the parkinsonian toxin 1-methyl-4-phenylpyridinium ion...

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PMID: 25017139
DOI: 10.1016/j.tox.2014.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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