Article
Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.
Nature - 20 Sept 2012
Venkatesh Swaminathan, Smolle Michaela, Li Hua, Gogol Madelaine M, Saint Malika, Kumar Shambhu, Natarajan Krishnamurthy, Workman Jerry L
Abstract excerpt
Set2-mediated methylation of histone H3 at Lys 36 (H3K36me) is a co-transcriptional event that is necessary for the activation of the Rpd3S histone deacetylase complex, thereby maintaining the coding region of genes in a hypoacetylated state. In the absence of Set2, H3K36 or Rpd3S acetylated histones accumulate on open reading frames (ORFs), leading to transcription initiation from cryptic promoters within ORFs....
Topics
- Acetylation
- Cell Cycle Proteins
- Genes, Fungal
- Histones
- Lysine
- Methylation
- Methyltransferases
- Molecular Chaperones
- Open Reading Frames
- Phenotype
- RNA Polymerase II