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Article

Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.

Nature - 20 Sept 2012

Venkatesh Swaminathan, Smolle Michaela, Li Hua, Gogol Madelaine M, Saint Malika, Kumar Shambhu, Natarajan Krishnamurthy, Workman Jerry L

Abstract excerpt

Set2-mediated methylation of histone H3 at Lys 36 (H3K36me) is a co-transcriptional event that is necessary for the activation of the Rpd3S histone deacetylase complex, thereby maintaining the coding region of genes in a hypoacetylated state. In the absence of Set2, H3K36 or Rpd3S acetylated histones accumulate on open reading frames (ORFs), leading to transcription initiation from cryptic promoters within ORFs....

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PMID: 22914091
DOI: 10.1038/nature11326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.PMID 22914091Read ↗

DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.Semantic proximity Read ↗

A nucleosome surface formed by histone H4, H2A, and H3 residues is needed for proper histone H3 Lys36 methylation, histone acetylation, and repression of cryptic transcription.Semantic proximity Read ↗

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.Semantic proximity Read ↗

Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.Semantic proximity Read ↗

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.Semantic proximity Read ↗

A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.Semantic proximity Read ↗

Balancing acts of SRI and an auto-inhibitory domain specify Set2 function at transcribed chromatin.Semantic proximity Read ↗

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.Semantic proximity Read ↗

Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulation of histone modification and cryptic transcription by the Bur1 and Paf1 complexes.Semantic proximity Read ↗

NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3.Semantic proximity Read ↗

A Histone Deacetylase Adjusts Transcription Kinetics at Coding Sequences during Candida albicans MorphogenesisSemantic proximity Read ↗

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