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Article

Assessment of genetic diversity of Plasmodium falciparum circumsporozoite protein in Sudan: the RTS,S leading malaria vaccine candidate.

Malaria journal - 10 Nov 2021

Mohamed Nouh Saad, AbdElbagi Hanadi, Elsadig Ahad R, Ahmed Abdalla Elssir, Mohammed Yassir Osman, Elssir Lubna Taj, Elnour Mohammed-Ahmed B, Ali Yousif, Ali Mohamed S, Altahir Omnia, Abubakr Mustafa, Siddig Emmanuel Edwar, Ahmed Ayman, Omer Rihab Ali

Abstract excerpt

BACKGROUND: The currently used malaria vaccine, RTS,S, is designed based on the Plasmodium falciparum circumsporozoite protein (PfCSP). The pfcsp gene, besides having different polymorphic patterns, can vary between P. falciparum isolates due to geographical origin and host immune response. Such aspects are essential when considering the deployment of the RTS,S vaccine in a certain region. Therefore, this study...

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Identifiers

PMID: 34758827
DOI: 10.1186/s12936-021-03971-0
PMCID: PMC8579544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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