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Article

Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases.

Nature communications - 1 Jan 2012

Watanabe Takahito, Ochiai Hiroshi, Sakuma Tetsushi, Horch Hadley W, Hamaguchi Naoya, Nakamura Taro, Bando Tetsuya, Ohuchi Hideyo, Yamamoto Takashi, Noji Sumihare, Mito Taro

Abstract excerpt

Hemimetabolous, or incompletely metamorphosing, insects are phylogenetically relatively basal and comprise many pests. However, the absence of a sophisticated genetic model system, or targeted gene-manipulation system, has limited research on hemimetabolous species. Here we use zinc-finger nuclease and transcription activator-like effector nuclease technologies to produce genetic knockouts in the hemimetabolous...

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Identifiers

PMID: 22910363
DOI: 10.1038/ncomms2020
PMCID: PMC3432469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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