Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila.

Nature - 30 Sept 1993

Zhao J J, Pick L

Abstract excerpt

The ability to isolate gene sequences and analyse their expression patterns has generated demand for mutations created to assess their biological functions. In Drosophila melanogaster this can be achieved by traditional mutagenesis, but this is time-consuming, labour-intensive and not always successful. Moreover, the functions of genes that are expressed several times during development are often obscured in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Base Sequence
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Molecular Sequence Data

Share to Phenotype

Source

Identifiers

PMID: 8413588
DOI: 10.1038/365448a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila.PMID 8413588Read ↗

Characterization of genetic loss-of-function of Fus in zebrafish.Semantic proximity Read ↗

Inserting the Ftz homeodomain into engrailed creates a dominant transcriptional repressor that specifically turns off Ftz target genes in vivo.Semantic proximity Read ↗

Genetic characterization of the homeodomain-independent activity of the Drosophila fushi tarazu gene product.Semantic proximity Read ↗

Low-level ectopic expression of Fushi tarazu in Drosophila melanogaster results in ftz(Ual/Rpl)-like phenotypes and rescues ftz phenotypes.Semantic proximity Read ↗

Deletion of morpholino binding sites (DeMOBS) to assess specificity of morphant phenotypes.Semantic proximity Read ↗

The basis for a heat-induced developmental defect: defining crucial lesions.Semantic proximity Read ↗

Homeodomain-independent activity of the fushi tarazu polypeptide in Drosophila embryos.Semantic proximity Read ↗

Synthetic oligonucleotides recreate Drosophila fushi tarazu zebra-stripe expression.Semantic proximity Read ↗

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases.Semantic proximity Read ↗

A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants.Semantic proximity Read ↗

Vectors and parameters that enhance the efficacy of RNAi-mediated gene disruption in transgenic Drosophila.Semantic proximity Read ↗

Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.