Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efficient gene targeting in Drosophila with zinc-finger nucleases.

Genetics - 1 Apr 2006

Beumer Kelly, Bhattacharyya Gargi, Bibikova Marina, Trautman Jonathan K, Carroll Dana

Abstract excerpt

This report describes high-frequency germline gene targeting at two genomic loci in Drosophila melanogaster, y and ry. In the best case, nearly all induced parents produced mutant progeny; 25% of their offspring were new mutants and most of these were targeted gene replacements resulting from homologous recombination (HR) with a marked donor DNA. The procedure that generates these high frequencies relies on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Temperature
Share to Drosophila melanogaster
Share to Endoribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Germ-Line Mutation

Share to Mutagenesis

Share to Recombination, Genetic

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 16452139
DOI: 10.1534/genetics.105.052829
PMCID: PMC1456366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efficient gene targeting in Drosophila with zinc-finger nucleases.PMID 16452139Read ↗

Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases.Semantic proximity Read ↗

Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila.Semantic proximity Read ↗

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases.Semantic proximity Read ↗

Using zinc finger nucleases for efficient and heritable gene disruption in zebrafish.Semantic proximity Read ↗

Inducing high rates of targeted mutagenesis in zebrafish using zinc finger nucleases (ZFNs).Semantic proximity Read ↗

Emerging gene knockout technology in zebrafish: zinc-finger nucleases.Semantic proximity Read ↗

Genome manipulation by homologous recombination in Drosophila.Semantic proximity Read ↗

Efficient allelic-drive in Drosophila.Semantic proximity Read ↗

Site-specific transgenesis of the <i>D. melanogaster</i> Y-chromosome using CRISPR/Cas9Semantic proximity Read ↗

Tuning Mitotic Recombination with Patterned DNA Nicks for Precision Mosaic AnalysisSemantic proximity Read ↗

Targeted genome editing in pluripotent stem cells using zinc-finger nucleases.Semantic proximity Read ↗

Gene targeting by homologous recombination in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.