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Article

Making designer mutants in model organisms.

Development (Cambridge, England) - 1 Nov 2014

Peng Ying, Clark Karl J, Campbell Jarryd M, Panetta Magdalena R, Guo Yi, Ekker Stephen C

Abstract excerpt

Recent advances in the targeted modification of complex eukaryotic genomes have unlocked a new era of genome engineering. From the pioneering work using zinc-finger nucleases (ZFNs), to the advent of the versatile and specific TALEN systems, and most recently the highly accessible CRISPR/Cas9 systems, we now possess an unprecedented ability to analyze developmental processes using sophisticated designer genetic...

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Identifiers

PMID: 25336735
DOI: 10.1242/dev.102186
PMCID: PMC4302887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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