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Article

IL-1R–MyD88 signaling in keratinocyte transformation and carcinogenesis

20 Aug 2012

Abstract excerpt

Constitutively active RAS plays a central role in the development of human cancer and is sufficient to induce tumors in two-stage skin carcinogenesis. RAS-mediated tumor formation is commonly associated with up-regulation of cytokines and chemokines that mediate an inflammatory response considered relevant to oncogenesis. In this study, we report that mice lacking IL-1R or MyD88 are less sensitive to topical skin...

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Identifiers

PMID: 22908325
DOI: 10.1084/jem.20101355

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