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Article

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.

Proceedings of the National Academy of Sciences of the United States of America - 16 Nov 2010

Brandl Katharina, Sun Lei, Neppl Christina, Siggs Owen M, Le Gall Sylvain M, Tomisato Wataru, Li Xiaohong, Du Xin, Maennel Daniela N, Blobel Carl P, Beutler Bruce

Abstract excerpt

Toll-like receptors (TLRs) trigger intestinal inflammation when the epithelial barrier is breached by physical trauma or pathogenic microbes. Although it has been shown that TLR-mediated signals are ultimately protective in models of acute intestinal inflammation [such as dextran sulfate sodium (...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21041656
DOI: 10.1073/pnas.1014669107
PMCID: PMC2993336

Genes

AREG
EREG
EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21041656-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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