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Article

Resistance of R-Ras knockout mice to skin tumour induction.

Scientific reports - 2 Jul 2015

May Ulrike, Prince Stuart, Vähätupa Maria, Laitinen Anni M, Nieminen Katriina, Uusitalo-Järvinen Hannele, Järvinen Tero A H

Abstract excerpt

The R-ras gene encodes a small GTPase that is a member of the Ras family. Despite close sequence similarities, R-Ras is functionally distinct from the prototypic Ras proteins; no transformative activity and no activating mutations of R-Ras in human malignancies have been reported for it. R-Ras activity appears inhibitory towards tumour proliferation and invasion, and to promote cellular quiescence. Contrary to...

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Identifiers

PMID: 26133397
DOI: 10.1038/srep11663
PMCID: PMC4488886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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