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IL-1α, Innate Immunity, and Skin Carcinogenesis: The Effect of Constitutive Expression of IL-1α in Epidermis on Chemical Carcinogenesis

1 Jun 2003

Abstract excerpt

Tumor promoters such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) are proinflammatory agents, and their mechanism of action in epithelial carcinogenesis has been linked to the release of IL-1 alpha and the induction of chronic inflammation in skin. To test the role of IL-1 alpha and inflammation in models of cutaneous carcinogenesis, we used our previously described FVB/N transgenic mice...

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PMID: 12759452
DOI: 10.4049/jimmunol.170.11.5697

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