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Article

Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation

17 Sept 2010

Abstract excerpt

Accumulating evidence points to inflammation as a promoter of carcinogenesis. MyD88 is an adaptor molecule in TLR and IL-1R signaling that was recently implicated in tumorigenesis through proinflammatory mechanisms. Here we have shown that MyD88 is also required in a cell-autonomous fashion for RAS-mediated carcinogenesis in mice in vivo and for MAPK activation and transformation in vitro. Mechanistically, MyD88...

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PMID: 20941850
DOI: 10.1172/jci42771

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