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Article

CD8(+) T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ.

The Journal of investigative dermatology - 1 Apr 2013

Gunderson Andrew J, Mohammed Javed, Horvath Frank J, Podolsky Michael A, Anderson Cherie R, Glick Adam B

Abstract excerpt

The RAS signaling pathway is constitutively activated in psoriatic keratinocytes. We expressed activated H-RAS(V12G) in suprabasal keratinocytes of adult mice and observed rapid development of a psoriasis-like skin phenotype characterized by basal keratinocyte hyperproliferation, acanthosis, hyperkeratosis, intraepidermal neutrophil microabscesses, and increased T helper type 1 (Th1)/Th17 and T cell type 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23151849
DOI: 10.1038/jid.2012.390
PMCID: PMC3577939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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